| 產(chǎn)品編號(hào) |
bs-8844R-HRP |
| 英文名稱 |
Rabbit Anti-SMAD8/HRP Conjugated antibody
|
| 中文名稱 |
辣根過氧化物酶標(biāo)記的SMAD8蛋白抗體 |
| 別 名 |
AI528653 ;
BSP 1 ;
BSP1 ;
DKFZp781C1895 ;
DKFZp781O1323 ;
Dwarfin A ;
Dwf A ;
DwfA ;
Dwfc ;
hSMAD1 ;
hSmad5 ;
JV 41 ;
JV4 1 ;
JV41 ;
JV5 1 ;
MAD (mothers against decapentaplegic, Drosophila) homolog 1 ;
MAD (mothers against decapentaplegic, Drosophila) homolog 9 ;
MAD homolog 1 ;
MAD homolog 9 ;
MAD homolog1 (mothers against decapentaplegic, Drosophila) ;
Mad related protein 1 ;
MAD, mothers against decapentaplegic homolog 9 ;
MADH 1 ;
Madh1 ;
MADH5 ;
MADH6 ;
MADH9 ;
Madr 1 ;
MADR1 ;
Mlp1 ;
Mothers against decapentaplegic, drosophila, homolog of, 9 ;
Mothers against DPP homolog 1 ;
Mothers against DPP homolog 9 ;
MusMLP ;
OTTHUMP00000178565 ;
OTTMUSP00000022970 ;
OTTMUSP00000022971 ;
OTTMUSP00000022972 ;
OTTMUSP0000002324 ;
OTTMUSP00000023428 ;
Sma and Mad related protein 1 ;
Sma- and Mad-related protein 1 ;
SMAD ;
SMAD family member 5 ;
SMAD mothers against DPP homolog 1 Drosophila ;
SMAD8 ;
SMAD8A ;
SMAD8B ;
Spinal muscular atrophy distal with upper limb predominance ;
TGF beta signaling protein 1 ;
Transforming growth factor beta signaling protein 1 ;
Transforming growth factor-beta signaling protein 1. |
| 規(guī)格價(jià)格 |
100ul/2980元
購(gòu)買 大包裝/詢價(jià) |
| 說 明 書 |
100ul
|
| 研究領(lǐng)域 |
腫瘤 細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 生長(zhǎng)因子和激素 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué) |
| 抗體來源 |
Rabbit |
| 克隆類型 |
Polyclonal |
| 交叉反應(yīng) |
(predicted: Human, Mouse, Rat, Zebrafish, )
|
| 產(chǎn)品應(yīng)用 |
WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
53kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human SMAD8 |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲(chǔ) 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Function:
Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway
Subcellular Location:
Cytoplasmic and Nuclear.
Similarity:
Belongs to the sphingomyelin synthase family.
Contains 1 SAM (sterile alpha motif) domain.
Database links:
Entrez Gene: 4086 Human
Entrez Gene: 4090 Human
Entrez Gene: 4093 Human
Entrez Gene: 17125 Mouse
Entrez Gene: 17129 Mouse
Entrez Gene: 55994 Mouse
Entrez Gene: 25671 Rat
Entrez Gene: 59328 Rat
Entrez Gene: 85435 Rat
Omim: 601595 Human
Omim: 603110 Human
Omim: 603295 Human
SwissProt: O15198 Human
SwissProt: Q15797 Human
SwissProt: Q99717 Human
SwissProt: P70340 Mouse
SwissProt: P97454 Mouse
SwissProt: Q9JIW5 Mouse
SwissProt: O54835 Rat
SwissProt: P97588 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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