| 產(chǎn)品編號(hào) | bs-18070R-Gold |
| 英文名稱 | Rabbit Anti-MHC class I/Gold Conjugated antibody |
| 中文名稱 | 膠體金標(biāo)記的組織相容性復(fù)合物A2抗體 |
| 別 名 | Antigen presenting molecule; HLA A; HLA A2; HLA A histocompatibility type; HLA; HLA class I; HLA class I histocompatibility antigen A 2 alpha chain; HLA class I histocompatibility antigen A2 alpha chain; HLA-A; HLAA; Human leukocyte antigen; Leucocyte antigen class I; Leukocyte antigen class I A; Major histocompatibility complex class I A; Major histocompatibility complex class I; MHC class I antigen [precursor]; MHC class I antigen A; MHC class I antigen A*2; MHC class I antigen A2; MHC class I antigen HLA A; MHC class I antigen HLA A heavy chain; MHC leukocyte antigen; 1A02_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書 | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 細(xì)胞膜蛋白 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, |
| 產(chǎn)品應(yīng)用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 38kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HLA A2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008] Function: Involved in the presentation of foreign antigens to the immune system. Dimer of alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein. Subcellular Location: Membrane; Single-pass type I membrane protein. Similarity: Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain. Database links: Entrez Gene: 3105 Human Omim: 142800 Human SwissProt: P04439 Human Unigene: 181244 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
