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Rabbit Anti-Homer (1b+1c)/BF488 Conjugated antibody (bs-17352R-BF488)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-17352R-BF488
英文名稱 Rabbit Anti-Homer (1b+1c)/BF488 Conjugated antibody
中文名稱 BF488標記的神經(jīng)細胞早期基因抗體
別    名 Homer 1; HOMER; Homer homolog 1; Homer protein homolog 1; Homer1; HOMER1B; HOMER1C; Neuronal immediate early gene; SYN47; Ves 1. HOME1_HUMAN  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細胞生物  神經(jīng)生物學(xué)  細胞類型標志物  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Rat,  (predicted: Mouse, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Homer (1b+1c)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]

Function:
Homer is a neuronal immediate early gene that is enriched at excitatory synapses and selectively binds metabotropic glutamate receptors.

Subunit:
Interacts with GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2,SHANK1 and SHANK3. Interacts with IFT57 and OPHN1. Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization.

Subcellular Location:
Cytoplasmic; Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Postsynaptic density of neuronal cells. Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum.

Similarity:
Belongs to the Homer family. Contains 1 WH1 domain.

Database links:

Entrez Gene: 9456 Human

Entrez Gene: 26556 Mouse

Entrez Gene: 29546 Rat

Omim: 604798 Human

SwissProt: Q86YM7 Human

SwissProt: Q9Z2Y3 Mouse

SwissProt: Q9Z214 Rat

Unigene: 591761 Human

Unigene: 37500 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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