| 產(chǎn)品編號 |
bs-14527R-BF488 |
| 英文名稱 |
Rabbit Anti-EHD3/BF488 Conjugated antibody
|
| 中文名稱 |
BF488標(biāo)記的EHD3蛋白抗體 |
| 別 名 |
EH domain containing 3;
EHD3_HUMAN;
EHD3;
PAST3. |
| 規(guī)格價(jià)格 |
100ul/2980元
購買 大包裝/詢價(jià) |
| 說 明 書 |
100ul
|
| 研究領(lǐng)域 |
細(xì)胞生物 轉(zhuǎn)運(yùn)蛋白 |
| 抗體來源 |
Rabbit |
| 克隆類型 |
Polyclonal |
| 交叉反應(yīng) |
Mouse,
(predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
|
| 產(chǎn)品應(yīng)用 |
ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
61kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human EHD3 |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
The Eps15 homology (EH) domain-containing protein family consists of four members, EHD1, EHD2, EHD3, and EHD4 (1). The chromosomal locations of the human EHD genes are as follows: EHD1 maps to 11q13, EHD2 maps to 19q13.3, EHD3 maps to 2p21, and EHD4 maps to 15q11.1 (1-3). The encoded proteins of all EHD family members contain multiple conserved regions, which include an amino-terminal nucleotide-binding consensus site, a bipartite nuclear localization signal, and a carboxy-terminal EH protein-binding domain with an EF-hand motif (3,4). EHD1 is ubiquitously expressed with increased expression in testis (2,3). EHD2, EHD3, and EHD4 have more specific expression with EHD2 highly expressed in heart, EHD3 expressed in brain, kidney, liver, placenta, ovary, and heart, and EHD4 expressed in heart, placenta, and pancreas (1,5,6). The EHD proteins may participate in ligand-induced endocytosis (3-5).
Function:
EHD3 contains one EF-hand domain and one EH domain. It plays a role in endocytic transport. EHD3 is highly expressed in heart and brain and moderately expressed in kidney, liver and placenta.
Subunit:
Homooligomer, and heterooligomer with EHD1, EHD2 and EHD4. Interacts with PACSIN1 and PACSIN2. Interacts (via EH domain) with MICALL1.
Subcellular Location:
Endosome membrane, cytoplasmic side. Nucleus.
Tissue Specificity:
Highly expressed in heart and brain and moderately expressed in kidney, liver, and placenta.
Similarity:
Contains 1 EF-hand domain.
Contains 1 EH domain.
Database links:
Entrez Gene: 30845 Human
Entrez Gene: 57440 Mouse
Omim: 605891 Human
SwissProt: Q9NZN3 Human
SwissProt: Q9QXY6 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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