| 產(chǎn)品編號(hào) | bs-14127R-BF488 |
| 英文名稱 | Rabbit Anti-CXXC4/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的CXXC型鋅指蛋白4抗體 |
| 別 名 | CXXC finger 4; CXXC finger protein 4; CXXC type zinc finger protein 4; CXXC-type zinc finger protein 4; Cxxc4; CXXC4_HUMAN; Dvl binding protein IDAX (inhibition of the Dvl and Axin complex); IDAX; Inhibition of the Dvl and axin complex protein; MGC149872. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 鋅指蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, (predicted: Human, Rat, Dog, Pig, Cow, Rabbit, Sheep, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 21kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CXXC4 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Idax is a 198 amino acid cytoplasmic protein that functions as a negative regulator of the Wnt signaling pathway through its interaction with the PDZ domain of Dvl-1. Containing one CXXC-type zinc finger, Idax is expressed at high levels in brain, with lower levels in testis and thymus. The gene encoding Idax maps to human chromosome 4, which represents approximately 6% of the human genome and contains nearly 900 genes. Notably, the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington's disease, is on chromosome 4. FGFR-3 is also encoded on chromosome 4 and has been associated with thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer. Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease. Function: Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1. Subcellular Location: Cytoplasm. Similarity: Contains 1 CXXC-type zinc finger. Database links: Entrez Gene: 80319 Human Entrez Gene: 319478 Mouse SwissProt: Q9H2H0 Human SwissProt: Q6NXI8 Mouse Unigene: 12248 Human Unigene: 224814 Mouse Unigene: 442744 Mouse Unigene: 457442 Mouse Unigene: 209562 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
