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Rabbit Anti-HHATL/Gold Conjugated antibody (bs-12315R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-12315R-Gold
英文名稱 Rabbit Anti-HHATL/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的甘油吸收/轉(zhuǎn)運(yùn)蛋白GUP1抗體
別    名 C3orf3; Glycerol uptake/transporter homolog; GUP1; GUP1 glycerol uptake/transporter homolog; Hedgehog acyltransferase like; Hedgehog acyltransferase-like protein; Hhatl; HHATL_HUMAN; KIAA1173; MBOAT3; Membrane bound O acyltransferase domain containing 3; MSTP002; OACT3; Protein-cysteine N-palmitoyltransferase HHAT-like protein.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 細(xì)胞生物  發(fā)育生物學(xué)  干細(xì)胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 57kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from Human HHATL/GUP1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
GUP1 is a 504 amino acid multipass membrane protein of the endoplasmic reticulum that functions as a membrane bound O-acyltransferase. With specific expression in heart, GUP1 negatively regulates amino-terminal palmitoylation of Shh by HHAT, a protein that is required for Shh signaling. Deletion of the gene encoding GUP1 results in higher sensibility to specific sphinogolipid biosynthesis inhibitors and resistance to ergosterol biosynthesis inhibitors, indicating that GUP1 is an essential component in lipid metabolism. Also, GUP1 also seems to be important for cell wall assembly and stability due to evidence in Saccharomyces cerevisiae GUP1 mutants, which exhibit altered plasma membrane lipid composition and membrane potential.

Function:
Negatively regulates N-terminal palmitoylation of SHH by HHAT/SKN.

Subunit:
Interacts with SHH (By similarity).

Subcellular Location:
Endoplasmic reticulum membrane.

Tissue Specificity:
Heart-specific.

Similarity:
Belongs to the membrane-bound acyltransferase family. HHAT subfamily.

Database links:

Entrez Gene: 57467 Human

Entrez Gene: 74770 Mouse

Entrez Gene: 301073 Rat

Omim: 608116 Human

SwissProt: Q9HCP6 Human

SwissProt: Q9D1G3 Mouse

Unigene: 476041 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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