| 產(chǎn)品編號(hào) |
bs-9736R-BF594 |
| 英文名稱 |
Rabbit Anti-D53/TPD52L1/BF594 Conjugated antibody
|
| 中文名稱 |
BF594標(biāo)記的腫瘤蛋白D53抗體 |
| 別 名 |
D53; D54; hD53; hD54; Tpd52l1; TPD52L2 TPD53_HUMAN; Tumor protein D52 like 1; Tumor protein D52 like 2; Tumor protein D52-like 1; Tumor protein D53; Tumor protein D54. |
| 規(guī)格價(jià)格 |
100ul/2980元
購買 大包裝/詢價(jià) |
| 說 明 書 |
100ul
|
| 研究領(lǐng)域 |
腫瘤 細(xì)胞生物 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞周期蛋白 激酶和磷酸酶 細(xì)胞分化 腫瘤細(xì)胞生物標(biāo)志物 |
| 抗體來源 |
Rabbit |
| 克隆類型 |
Polyclonal |
| 交叉反應(yīng) |
|
| 產(chǎn)品應(yīng)用 |
ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
22kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human TPD52L1/D53 |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲(chǔ) 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
The cell commits to dividing during the G2/M phase transition, and the timing of mitotic entry is tightly regulated to guarantee correct chromosome segregation. D53, also referred to as tumor protein D52-like 1 (TPD52L1), is a coiled-coil motif-bearing member of the D52 tumor protein family. D53 intereacts with 14-3-3, a negative regulator of the G2/M transition, in breast cancer cells. Expression of D53 is highly upregulated at the G2/M phase transition in breast cancer cell lines, and deregulated expression of this protein can adversely affect the completion of mitosis. D53 may function as a signaling intermediate and/or regulator of vesicle trafficking and cell proliferation.
Subunit:
Forms a homodimer or heterodimer with other members of the family.
Similarity:
Belongs to the TPD52 family.
Database links:
Entrez Gene: 7164 Human
Entrez Gene: 21987 Mouse
Omim: 604069 Human
SwissProt: Q16890 Human
SwissProt: O54818 Mouse
Unigene: 591347 Human
Unigene: 439966 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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