| 產(chǎn)品編號 |
bs-6294R-RBITC |
| 英文名稱 |
Rabbit Anti-beta 2 Microglobulin/RBITC Conjugated antibody
|
| 中文名稱 |
羅丹明（RBITC）標(biāo)記的β2-微球蛋白/β2微球蛋白抗體 |
| 別 名 |
B2M; Beta 2 microglobulin precursor; Beta-2 Microglobulin; Beta chain of mhc class 1 proteins; Hdcma22p; B2MG_HUMAN; Beta 2 microglobin; Beta 2 microglobulin precursor; Beta chain of mhc class 1 proteins; Beta chain of MHC class I molecules; Beta-2-microglobulin form pI 5.3; CDABP0092. |
| 規(guī)格價(jià)格 |
100ul/2980元
購買 大包裝/詢價(jià) |
| 說 明 書 |
100ul
|
| 研究領(lǐng)域 |
腫瘤 心血管 腫瘤細(xì)胞生物標(biāo)志物 |
| 抗體來源 |
Rabbit |
| 克隆類型 |
Polyclonal |
| 交叉反應(yīng) |
Human, Mouse,
(predicted: Rat, )
|
| 產(chǎn)品應(yīng)用 |
IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
12kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human beta 2 Microglobulin |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Sep 2009].
Function:
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
Subunit:
Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis.
Subcellular Location:
Secreted. Detected in serum and urine.
Post-translational modifications:
Glycation of Ile-21 is observed in long-term hemodialysis patients.
DISEASE:
Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.
Similarity:
Belongs to the beta-2-microglobulin family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Database links:
Entrez Gene: 567 Human
Entrez Gene: 12010 Mouse
Entrez Gene: 24223 Rat
Omim: 109700 Human
SwissProt: P61769 Human
SwissProt: P01887 Mouse
SwissProt: P07151 Rat
Unigene: 534255 Human
Unigene: 702947 Human
Unigene: 163 Mouse
Unigene: 1868 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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