| 產(chǎn)品編號(hào) | bs-6044R-APC |
| 英文名稱 | Rabbit Anti-Delta 4/APC Conjugated antibody |
| 中文名稱 | APC標(biāo)記的Notch信號(hào)通路Delta樣配體4抗體 |
| 別 名 | Delta 4; delta 4 precursor; Delta-4: Delta ligand 4; delta ligand 4 precursor; Delta like 4; Delta like 4 homolog; Delta like 4 protein; Delta like protein 4; Delta-like 4 (Drosophila); Delta-like protein 4; Delta4; DLL 4; DLL4; DLL4_HUMAN antibody Drosophila Delta homolog 4; hdelta2; Homeobox protein DLL-4; MGC126344; Notch ligand delta 2; Notch ligand DLL4; notch ligand DLL4 precursor; XDLL-4. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 細(xì)胞周期蛋白 細(xì)胞膜受體 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, (predicted: Human, Rat, Dog, Pig, Cow, Horse, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 72kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DLL4 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for Notch include Jagged, Jagged-2 and Delta. While blocking the differentiation of progenitor cells into the B-cell lineage, Delta promotes the emergence of a population of cells with T cell/NK-cell characteristics. The protein is a membrane protein expressed in heart, pancreas, brain and muscle during gastrulation and early organogenesis and in adult heart and lung. Delta-4 is a membrane protein that activates Notch-1 and Notch-4. It is expressed in a wide range of adult and fetal tissues, especially in vascular endothelium. Function: Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4. Subunit: Binds to Notch-1 and Notch-4 (By similarity). Subcellular Location: Membrane; Single-pass type I membrane protein (Probable). Tissue Specificity: Expressed in vascular endothelium. Post-translational modifications: Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation. Similarity: Contains 1 DSL domain. Contains 8 EGF-like domains. Database links: Entrez Gene: 54567 Human Entrez Gene: 54485 Mouse Omim: 605185 Human SwissProt: Q9NR61 Human SwissProt: Q9JI71 Mouse Unigene: 511076 Human Unigene: 143719 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
