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phospho-Dopamine Transporter (Thr53) Rabbit pAb (bs-14408R)  
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產(chǎn)品編號 bs-14408R
英文名稱 phospho-Dopamine Transporter (Thr53) Rabbit pAb
中文名稱 磷酸化多巴胺轉(zhuǎn)運蛋白DAT抗體
別    名 Dopamine Transporter(phospho T53); p-Dopamine Transporter(phospho T53); p-DAT1(phospho T53); DA transporter; DAT 1; DAT; SC6A3_RAT; DAT1; Dopamine transporter 1; PKDYS; SC6A3_HUMAN; SLC6A3; Sodium dependent dopamine transporter; Sodium-dependent dopamine transporter; Solute carrier family 6(neurotransmitter transporter dopamine), member 3; Solute carrier family 6(neurotransmitter transporter), member 3; Solute carrier family 6 member 3; Variable number tandem repeat(VNTR).  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 細胞生物  神經(jīng)生物學(xué)  結(jié)合蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應(yīng) Mouse,Rat (predicted: Horse)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 69 kDa
檢測分子量
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from mouse Dopamine Transporter around the phosphorylation site of Thr53: PQ(p-T)PV 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.[provided by RefSeq, Nov 2009]

Function:
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.

Subcellular Location:
Membrane.

DISEASE:
Defects in SLC6A3 are the cause of dystonia-parkinsonism infantile (DYTPRI) [MIM:613135]. It is a neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradikinesia and pyramidal tract signs.

Similarity:
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.

SWISS:
Q61327

Gene ID:
13162

Database links:

Entrez Gene: 6531 Human

Entrez Gene: 13162 Mouse

Entrez Gene: 24898 Rat

Omim: 126455 Human

SwissProt: Q01959 Human

SwissProt: Q61327 Mouse

SwissProt: P23977 Rat

Unigene: 406 Human

Unigene: 41993 Mouse

Unigene: 10093 Rat




產(chǎn)品圖片
Sample: Lane 1: Cerebrum (Mouse) Lysate at 40 ug Lane 2: Cerebrum (Rat) Lysate at 40 ug Primary: Anti-phospho-Dopamine Transporter (Thr53) (bs-14408R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 69 kD Observed band size: 95 kD
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