| 產(chǎn)品編號 |
bs-10142R |
| 英文名稱 |
ZFAND5 Rabbit pAb
|
| 中文名稱 |
AN1型鋅指蛋白5抗體 |
| 別 名 |
AN1-type zinc finger protein 5; ZA20D2; ZFAN5_HUMAN; Zfand5; ZFAND5A; zinc finger A20 domain containing 2; Zinc finger A20 domain containing protein 2; Zinc finger A20 domain-containing protein 2; zinc finger AN1 type domain 5; Zinc finger protein 216; ZNF216. |
| 研究領域 |
細胞生物 染色質(zhì)和核信號 信號轉(zhuǎn)導 細胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子 細胞外基質(zhì) 表觀遺傳學 |
| 抗體來源 |
Rabbit |
| 克隆類型 |
Polyclonal
|
| 克 隆 號 |
|
| 交叉反應 |
(predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Chicken)
|
| 產(chǎn)品應用 |
IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 |
23 kDa |
| 檢測分子量 |
|
| 細胞定位 |
細胞漿
|
| 性 狀 |
Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human ZFAND5: 121-213/213 |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 緩 沖 液 |
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 |
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed |
PubMed |
| 產(chǎn)品介紹 |
Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Could be involved in regulating NF-kappa-B activation and apoptosis. Is a potent inhibitory factor for osteoclast differentiation. Involved in protein degradation via the ubiquitin-proteasome system and plays a critical role in muscle atrophy. May act by anchoring ubiquitinylated proteins to the proteasome, playing a critical role in protein degradation.
Function:
Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.
Subunit:
Interacts with ubiquitin and polyubiquitinated proteins. Identified in a heterotrimeric complex with ubiquitin and SQSTM1, where ZFAND5 and SQSTM1 both interact with the same ubiquitin molecule (By similarity). Homooligomer and/or heterooligomer. Interacts (via A20-type domain) with IKBKG and RIPK1 and with TRAF6 (via AN1-type domain).
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Highly expressed in skeletal muscle. Expressed in fetal cochlea. Also expressed in infant brain, fetal heart, pancreatic islet, melanocyte, pineal gland, placenta, corneal stroma, and parathyroid tumor. Weakly expressed or undetectable in adult brain, heart, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. Expressed in rhabdomyosarcoma RD cells (at protein level).
Similarity:
Contains 1 A20-type zinc finger.
Contains 1 AN1-type zinc finger.
SWISS:
O76080
Gene ID:
7763
Database links:
Entrez Gene: 7763 Human
Entrez Gene: 22682 Mouse
Entrez Gene: 293960 Rat
Omim: 604761 Human
SwissProt: O76080 Human
SwissProt: O88878 Mouse
SwissProt: B5DF11 Rat
Unigene: 406096 Human
Unigene: 292405 Mouse
Unigene: 379919 Mouse
Unigene: 4050 Rat
|
|
|
