| 產(chǎn)品編號 | bs-8472R |
| 英文名稱 | FBXO11 Rabbit pAb |
| 中文名稱 | F-box蛋白相關(guān)蛋白11抗體 |
| 別 名 | F box protein 11; F-box only protein 11; FBX11; FBX11_HUMAN; Fbxo11; Fbxo 11; Fbxo-11; PRMT9; VIT-1; VIT1; Vitiligo associated protein VIT 1; Vitiligo-associated protein 1. |
| 研究領(lǐng)域 | 細胞生物 免疫學(xué) 泛素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Chicken,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 104 kDa |
| 檢測分子量 | |
| 細胞定位 | 細胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FBXO11: 65-160/927 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a member of the F-box protein familywhich is characterized by an approximately 40 amino acid motif, theF-box. The F-box proteins constitute one of the four subunits ofubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),which function in phosphorylation-dependent ubiquitination. TheF-box proteins are divided into 3 classes: Fbws containing WD-40domains, Fbls containing leucine-rich repeats, and Fbxs containingeither different protein-protein interaction modules or norecognizable motifs. The protein encoded by this gene belongs tothe Fbxs class. It can function as an arginine methyltransferasethat symmetrically dimethylates arginine residues, and it acts asan adaptor protein to mediate the neddylation of p53, which leadsto the suppression of p53 function. This gene is known to bedown-regulated in melanocytes from patients with vitiligo, a skindisorder that results in depigmentation. Polymorphisms in this geneare associated with chronic otitis media with effusion andrecurrent otitis media (COME/ROM), a hearing loss disorder, and theknockout of the homologous mouse gene results in the deaf mousemutant Jeff (Jf), a single gene model of otitis media.Alternatively spliced transcript variants encoding distinctisoforms have been identified for this gene. [provided by RefSeq,Jun 2010]. Function: Substrate recognition component of the a(SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex whichmediates the ubiquitination and subsequent proteasomal degradationof target proteins. Probably recognizes and binds to phosphorylatedtarget proteins. Binds to and neddylates phosphorylated p53/TP53,inhibiting its transcriptional activity. SCF(FBXO11) does not seemto direct ubiquitination of TP53. Subunit: Component of the probable SCF(FBXWO11) complex consisting of CUL1, RBX1, SKP1 and FBXO11. Interacts with TP53. Subcellular Location: Nucleus Tissue Specificity: Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes. Similarity: Contains 1 F-box domain. Contains 19 PbH1 repeats. Contains 1 UBR-type zinc finger. SWISS: Q86XK2 Gene ID: 80204 Database links: Entrez Gene: 80204 Human Entrez Gene: 225055 Mouse Omim: 607871 Human SwissProt: Q86XK2 Human SwissProt: Q7TPD1 Mouse Unigene: 352677 Human Unigene: 386857 Mouse Unigene: 36585 Rat |
